Nanoscience Seminar: Xing Wang
- Start the deep understanding of DNA homologous pairing with a complex designer DNA motif
- Dr. Xing Wang, Rensselaer Polytechnic Institute (RPI)
- How two homologous chromosomes find each other in the cell with nearly unfailing fidelity remains largely a mystery. Specifically, recombination-independent homologous pairing (HP) is one of the fundamental processes of life, playing vital roles in crucial biological processes (during both sexual reproduction and vegetative cell proliferation), including preparation for double-stranded break (DSB) repair and meiotic homologous recombination (HR), X-chromosome expression inactivation, V(D)J recombination and genomic imprinting, and proper chromosome segregation. Elucidation of the underlying mechanism for HP will have broad implications for basic biology, molecular evolution, genetic diseases and genome manipulation. Unfortunately, current models have not provided much insight into the molecular-level mechanism of the process, largely due to the lack of an explicit molecular structure of HP. Paranemic crossover (PX) DNA has been recently implicated as the molecular structure for HP. In this presentation, I will talk about our past and ongoing efforts to experimentally determine the structural identity of HP and computationally design a sensor for PX/HP to enable the profiling and monitoring of HP in living cells.
- Dr. Xing Wang is an assistant professor in the Department of Chemistry and Chemical Biology & Center for Biotechnology and Interdisciplinary Studies at Rensselaer Polytechnic Institute. He received his Ph.D. in Chemistry from New York University (2009). After a postdoctoral training at Princeton University exploring the novel functions of noncoding RNAs, he joined the faculty of Rensselaer in 2014. Dr. Wang's Nucleic Acids Programming Lab at RPI is currently focused on the design and synthesis of DNA/RNA aptamers, functional DNA-based nanostructures and nanodevices, and on the exploration of their uses in energy harvesting, basic biology, diagnostics in low-resource environment, and therapeutics.
October 25, 2018
2:00 PM — 3:00 PM
Advanced Science Research Center, GC/CUNY
85 St. Nicholas Terrace
5th Floor - Data Visualization Room