Nanoscience Seminar: Iva Pashkuleva
- Glycans as multifunctional building blocks for biomaterials.
- Iva Pashkuleva, University of Minho, Portugal
- Glycans together with proteins are key element of the extracellular and pericellular environment where they determine the physical characteristics of tissues and modulate the biological functions of cells. Beside their multiple bioactivities, glycans have been overlooked as building blocks for supramolecular systems targeting biomedical applications. Their scanty use is mainly due to (i) the complex chemistry: multistep modification methods are usually required to tailor glycans to a certain system and these modifications often affect their bioactivity and (ii) involvement of multivalent weak biointeractions that are difficult to quantify.
- The talk will focus on several recent strategies designed in our lab to overcome the above-mentioned difficulties and to develop glycan-based supramolecular systems of different complexity and for different biomedical applications. The engagement of distinct processes such as interfacial complexation, polyelectrolyte complexation, and self-assembly in the fabrication of glycan-based hydrogels, fibers of different length scales and nanoparticles will be discussed. It will be demonstrated that the sulfation of glycans associated with their intrinsic negative charge is of main importance in these approaches because most of the developed nanosystems are based on electrostatic or specific multivalent interactions. The application of the developed systems in different bioscenarios will be also presented - protein delivery systems, platforms for stem cell differentiation and artificial mimics of extracellular matrix are some of the examples that will be addressed.
August 17, 2018
Advanced Science Research Center, GC/CUNY
85 St. Nicholas Terrace
5th Floor Data Visualization Room